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我们根据临床需要,将阴道塞药制成泡腾片,治疗阴道炎、宫颈炎等,效果良好。泡腾片系将主药以碳酸氢钠与枸橼酸、酒石酸等有机酸混合为辅料制片。外用片改用价廉的硼酸代替。泡腾片发挥作用的机理是,在有少量阴道分泌液存在的情况下,发生酸碱中和反应,产生二氧化碳气泡使片剂迅速崩解。由于产生的气泡细小而持久,使主药均匀分布在大量泡沫中而充盈腔道。泡腾片崩解快、分散好、疗效高,且工艺简单,成本低廉,便于使用。这种片剂在制备、包装与贮存时,应严格避免与潮气接触,以保持泡腾作用。现将几种
We based on clinical needs, the vaginal plug medicine made effervescent tablets, the treatment of vaginitis, cervicitis, etc., the effect is good. Effervescent tablets will be the main drug to sodium bicarbonate and citric acid, tartaric acid and other organic acids mixed as an excipient preparation. External film replaced with inexpensive boric acid instead. Effervescent tablet to play a role in the mechanism is that in the presence of a small amount of vaginal secretions, the occurrence of acid-base neutralization reaction, resulting in carbon dioxide bubble tablet rapidly disintegration. Due to the small and persistent bubbles, the main drug is evenly distributed in a large number of foam to fill the cavity. Effervescent tablet disintegration fast, decentralized, high efficacy, and the process is simple, low cost, easy to use. This tablet in the preparation, packaging and storage, should be strictly avoid contact with moisture to maintain effervescent effect. Now several