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以大鼠条件性回避反应的习得作为学习的指标，观察了海马内注射ＡＣＴＨ的促学习作用，以及海马内注射β受体阻断剂普萘洛尔对这一作用的拮抗效应。结果如下：（１）ＡＣＴＨ组（０．２ＩＵ／２μｌ，ｉｈ）和生理盐水组（２μｌ，ｉｈ），随着训练，条件性回避反应的习得率呈逐日上升的现象，尤以ＡＣＴＨ组更为显著（Ｐ＜０．０５～０．０１）；（２）普萘洛尔（０．１ｍｇ／２μｌ，ｉｈ）有显著拮抗ＡＣＴＨ易化条件性回避反应的作用（Ｐ＜０．０１～０．００１）。由此表明，ＡＣＴＨ通过海马起促学习作用，海马中去甲肾上腺素能系统β受体介入了这一促学习过程。
The conditional avoidance response in rats was used as an indicator of learning to observe the promoting effect of intrahippocampal injection of ACTH and the antagonistic effect of propranolol, a beta blocker in hippocampus, on this effect. The results were as follows: (1) ACTH group (0.2IU / 2μl, ih) and saline group (2μl, ih), with the training, the learning rate of conditioned avoidance reaction was rising day by day, (P <0.05-0.01). (2) Propranolol (0.1mg / 2μl, ih) had a significant antagonistic effect on ACTH facilitation (P <0.01-0 .001). This suggests that ACTH promotes learning through the hippocampus and that the beta-adrenergic receptor in the hippocampus is involved in this learning process.