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40多年前,Freund等证明,油包水(W/O)乳剂能提高对多种抗原的抗体应答,但是,由于它们能引起机体的慢性炎症或无菌性脓肿,所以实用价值不大;而水包油(O/W)乳剂正在兴起,至今还没有发现稀
More than 40 years ago, Freund et al. Demonstrated that water-in-oil (W / O) emulsions increase the antibody response to multiple antigens, but are of little practical value because they can cause chronic inflammation or aseptic abscesses in the body; Oil-in-water (O / W) emulsions are on the rise and so far none have been found