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联苯胺对动物诱发肿瘤,有种属差异。地鼠为肝肿瘤、肝癌、胆管瘤,兔和狗为膀胱肿瘤。对人的致癌有流行病学方面的资料:Huepper曾报道了各国联苯胺首先引起膀胱肿瘤的年份。德国最早出现为1895年,继之有瑞士、英国、苏联、美国、澳大利亚、意大利、日本,法国最晚为1946年等。调查发现联苯胺引起膀胱肿瘤的年份与染料工业建立的早晚有关。建立早者则发病早,晚者则发病也晚。从Haley(1975)的文献综述中可查到已经报告的病例数为1,798例,如表1,也有的人说已报告
Benzidine on animal-induced tumors, there are species differences. Hamsters for liver cancer, liver cancer, cholangiocarcinoma, rabbits and dogs for the bladder tumor. Epidemiological data on human carcinogen: Huepper reported the year that benzidine first caused bladder tumors in various countries. Germany first appeared in 1895, followed by Switzerland, Britain, the Soviet Union, the United States, Australia, Italy, Japan, France at the latest such as 1946 and so on. The survey found that benzidine caused bladder cancer in the year and the establishment of the dye industry sooner or later. The early onset of onset is established, late onset is late. A review of the literature by Haley (1975) shows that 1,798 cases have been reported, as shown in Table 1 and others have reported