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血脑屏障内皮细胞的紧密连接在控制细胞进入中枢神经系统的过程中起关键作用。HIV-1病毒蛋白如gp120具有神经毒性和细胞毒性,HIV感染的单核吞噬细胞可穿越血脑屏障引起神经系统损伤,导致人类免疫缺陷病毒相关性脑病(HAD)。滥用甲基苯丙胺(Meth)可改变血脑屏障的通透性,加重HAD
The tight junction of the blood-brain barrier endothelial cells plays a key role in controlling the cells’ entry into the central nervous system. HIV-1 viral proteins such as gp120 are neurotoxic and cytotoxic and HIV-infected mononuclear phagocytes can cross the blood-brain barrier to cause nervous system damage resulting in human immunodeficiency virus-associated encephalopathy (HAD). Methyl abuse can alter the permeability of the blood-brain barrier and increase HAD