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目的:观察和胃化湿汤辅助质子泵抑制剂治疗老年消化性溃疡临床疗效及安全性。方法:收集我院胃肠科收治的老年消化性溃疡患者70例,随机分为试验组和对照组,各35例。对照组予以质子泵抑制剂治疗;试验组在对照组的基础上予以和胃化湿汤每日1剂。2组均以4周为1个疗程,共治疗2个疗程。结果:治疗后与对照组相比,试验组临床总有效率较高(P<0.05)。治疗后2组PGI、PGR、MOT水平均出现升高(P<0.05),试验组PGI、PGR、MOT水平明显高于对照组(P<0.05)。与治疗前相比2组白介素-17、白介素-2水平降低(P<0.05),与对照组相比,试验组白介素-17、白介素-2水平较低(P<0.05)。2组超氧化岐化酶、一氧化氮水平升高,过氧化脂质降低(P<0.05),与对照组相比,试验组超氧化岐化酶、一氧化氮水平较高,过氧化脂质较低(P<0.05)。结论:和胃化湿汤辅助质子泵抑制剂治疗老年消化性溃疡临床疗效显著,安全性高。
Objective: To observe the efficacy and safety of Weishutang decoction combined with proton pump inhibitor in the treatment of senile peptic ulcer. Methods: Seventy patients with senile peptic ulcer admitted to our department of gastroenterology were randomly divided into experimental group and control group with 35 cases each. The control group was treated with proton pump inhibitor; the experimental group was given qihuazhu decoction once a day on the basis of the control group. 2 groups were 4 weeks for a course of treatment, a total of 2 courses of treatment. Results: After treatment, compared with the control group, the experimental group had a higher total effective rate (P <0.05). The levels of PGI, PGR and MOT increased in both groups after treatment (P <0.05). The levels of PGI, PGR and MOT in the experimental group were significantly higher than those in the control group (P <0.05). The levels of interleukin-17 and interleukin-2 in the two groups were significantly lower than those before treatment (P <0.05). Compared with the control group, the levels of interleukin-17 and interleukin-2 in the experimental group were lower (P <0.05). Compared with the control group, the levels of superoxide dismutase and nitric oxide in the experimental group were higher than those in the control group. The level of superoxide dismutase Lower quality (P <0.05). Conclusions: The clinical curative effect of HGHP-assisted proton pump inhibitor on senile peptic ulcer is remarkable and safe.