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目的研究多巴胺D1和D3受体在运动调控中发挥的不同作用。方法60只小鼠随机分为多巴胺D3受体基因敲除组、多巴胺D1受体基因敲除组和野生型对照组,每组各20只;通过旷场实验和转棒实验,观察多巴胺D1和D3受体基因敲除小鼠运动能力的改变。结果在旷场实验和转棒实验中,多巴胺D1受体基因敲除组小鼠与野生型对照组比较,运动协调能力显著减弱(P<0.01);多巴胺D3受体基因敲除组小鼠与野生型对照组比较,运动行为能力改变不明显。结论多巴胺D1受体在运动调控中起着比较重要的作用,D3受体在运动调控中的作用不很明显。
Objective To study the different roles played by dopamine D1 and D3 receptors in motor regulation. Methods Sixty mice were randomly divided into three groups: dopamine D3 receptor knockout group, dopamine D1 receptor knockout group and wild type control group, with 20 rats in each group. Through open-field test and rotarod test, dopamine D1 and D3 receptor gene knockout mice exercise capacity changes. Results In the open-field test and the rotarod test, compared with the wild-type control group, the dopamine D1 receptor gene knock-out group significantly reduced the motor coordination ability (P <0.01); dopamine D3 receptor knockout group Wild-type control group, no significant changes in motor performance. Conclusion Dopamine D1 receptor plays a more important role in motor regulation. The role of D3 receptor in motor regulation is not obvious.