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在保留芦氟沙星（ｒｕｆｌｏｘａｃｉｎ）母核基本骨架的基础上进行结构修饰，以７，８二氟３，４二氢１，４苯并噻嗪为起始原料，经缩合环合、螯合、亲核取代、水解反应，合成了７个化合物，并测试了其体外抑菌活性，其中化合物（Ⅳ１）的体外抑菌活性优于芦氟沙星
The structure of the basic skeleton of the rufloxacin mother nucleus is preserved on the basis of retaining 7,8-difluoro-3,4-dihydro-1,4-benzothiazine as a starting material and condensation Seven compounds were synthesized and their antibacterial activity in vitro was tested. The antibacterial activity of compound (Ⅳ1) in vitro was better than that of rufloxacin