论文部分内容阅读
索戈托病毒属于正黏病毒家族,是一种由蜱传播给人或动物的虫媒病毒,其基因结构特征、复制及转录、编码产物的功能等与流感病毒有诸多相似之处,对流感病毒保守位点的探究具有重要意义,而且索戈托病毒属病毒的动物模型有望作为人感染高致病性流感病毒的一个替代模型。不过迄今为止全球对索戈托病毒的研究尚少,尚未引起足够的重视。本文主要对索戈托病毒的分类、基因组成及各基因编码产物、进化特点等进行了介绍,重点总结了其第六个基因片段编码的基质蛋白M和ML蛋白在病毒复制周期中所发挥的作用以及病毒与宿主间的相互作用机制等方面的研究进展。
Sogotovirus belongs to the family of orthomyxoviruses and is an arbovirus transmitted by ticks to humans and animals. Its gene structure, replication and transcription, and the function of the encoded product have many similarities with the influenza virus, The investigation of conserved sites in the virus is of great importance, and the animal model of the genus Vothogovirus is expected to serve as a surrogate model for human infection with the highly pathogenic influenza virus. However, so far the global research on the Sonogo virus is still scarce and not enough attention has been paid to it. In this paper, the classification, gene composition, gene encoding products and evolutionary features of Sogotovirus were mainly introduced, and the matrix proteins M and ML encoded by the sixth gene fragment were summarized in the viral replication cycle As well as the mechanism of virus-host interaction.