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2012年8月至2013年8月间,从南海医院内分泌科收集60岁以上高血压合并糖尿病患者545例,采用简化MDRD公式计算eGFR,根据eGFR水平将其分为正常组及下降组,应用Binary logistic回归方法对eGFR的相关危险进行分析。结果回归分析显示年龄(OR=1.054,P=0.001)、BMI(OR=1.097,P=0.023)、HbA1c(OR=1.328,P<0.001)、UA(OR=1.003,P=0.001)、高血压家族史(OR=5.336,P=0.001)、吸烟史(OR=2.085,P=0.029)与eGFR下降呈独立正相关,HDL-C(OR=0.487,P=0.012)与eGFR下降呈独立负相关。结论老年糖尿病合并高血压患者应使用eGFR评估肾功能情况,并严格控制血压、血糖、血脂及血尿酸水平,以减少慢性肾脏疾病的发生风险。
From August 2012 to August 2013, 545 hypertensive patients with diabetes over 60 years old were collected from Department of Endocrinology, Nanhai Hospital, and eGFR was calculated by simplified MDRD formula. According to eGFR level, eGFR was divided into normal group and descending group. Binary Logistic regression analysis of eGFR-related risks. Results The results of regression analysis showed that age (OR = 1.054, P = 0.001), BMI (OR = 1.097, P = 0.023), HbA1c (OR = 1.328, Family history (OR = 5.336, P = 0.001) and smoking history (OR = 2.085, P = 0.029) were independently and positively correlated with eGFR decline. There was a negative correlation between HDL-C (OR = 0.487, P = 0.012) . Conclusion Elderly patients with diabetes mellitus and hypertension should use eGFR to assess renal function, and strictly control blood pressure, blood glucose, blood lipid and serum uric acid levels in order to reduce the risk of chronic kidney disease.