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本文经复习有关文献资料,发现在438例长期血透患者中肾囊肿病发生率为36.5%(160例),即在原先无囊肿的肾脏出现双侧性多发性囊肿,并被认为是癌前病变。在上述160例获得性肾囊肿病中25%(40例)发现有肾肿瘤。有人推断这种肿瘤是从肾小管上皮细胞的增殖灶上发生的。这种上皮细胞是此类和其他肾囊肿病的特征。这些肿瘤中17.5%(7例)为肾腺癌,2例有转移。在非囊肿病患者中均未发现肿瘤或腺癌。根据上述资料,在长期血透患者中约每63例有1例发生肾腺癌,且都发生肾囊肿病患者。每23例囊肿病中有1例肾腺癌,且每80例中有1例转移。在获得性囊肿病的患者中肾腺癌的发生率比正常人高出7倍(P<0.00001)。比慢性肾衰患者高14倍(P<0.00004)。
This article reviewed the literature, found that in 438 cases of long-term hemodialysis patients, the incidence of renal cyst disease was 36.5% (160 cases), that is, in the original non-cyst kidney appear bilateral multiple cysts and is considered pre-cancerous Lesions. Renal tumors were found in 25% (40 cases) of the 160 patients with acquired renal cysts. It has been speculated that this tumor occurs from the proliferative focus of renal tubular epithelial cells. Such epithelial cells are characteristic of this and other renal cystic diseases. Of these tumors, 17.5% (7 cases) had renal adenocarcinoma and 2 had metastases. No tumor or adenocarcinoma was found in patients with non-cystic disease. According to the above information, in about 63 cases of long-term hemodialysis patients, there is 1 case of renal adenocarcinoma, and all patients with renal cysts. One case of renal adenocarcinoma was found in 23 cases of cyst disease and one case was transferred in 80 cases. The incidence of renal adenocarcinoma in patients with acquired cystic disease is 7 times higher than in normal people (P <0.00001). 14 times higher than those with chronic renal failure (P <0.00004).