Synthesis of a New Rigid Bicyclic AMPP Ligand (TIAMPP) and Application in Asymmetric Hydrogenation

• 出 处: Chinese Chemical Letters
• 发表日期: 2005年09期
• 关键词: Ligand hydrogenation alcohol chiral asymmetric afford backbone retention carboxy

The new rigid bicyclic AMPP((S)-TIAMPP) has been synthesized from the correspond- ing Ticol and Ph2PCl. The application of (S)-TIAMPP in Rh-catalyzed asymmetric hydrogenation of α-dehydroamino acids derivatives has been examined. Up to 93% ee was obtained.

The new rigid bicyclic AMPP ((S) -TIAMPP) has been synthesized from the corresponding Ticol and Ph2PCl. The application of (S) -TIAMPP in Rh-catalyzed asymmetric hydrogenation of a-dehydroamino acid derivatives has been examined. Up to 93% ee was obtained.