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目的通过盐酸阿比朵尔的体内抗病毒及免疫功能的研究,探讨盐酸阿比朵尔治疗病毒性心肌炎的可能机制。方法以柯萨奇B3病毒构建小鼠病毒性心肌炎模型,灌胃给予不同浓度的盐酸阿比朵尔药液治疗7d、30d后,分别测定小鼠心肌病毒滴度和部分免疫指标。结果盐酸阿比朵尔3个剂量组与病毒对照组的㏒TCID50差值均大于1,并且可以诱生小鼠体内IFN水平升高,LPO含量降低,SOD活性增强,促进小鼠淋巴细胞的增值反应,提升小鼠NK细胞的杀伤活性,抑制心肌酶LDH的释放。结论盐酸阿比朵尔对病毒性心肌炎具有明显地治疗作用,其作用途径是多方面的,但是免疫功能的调节及体内氧自由基的快速清除可能是其治疗病毒性心肌炎的主要机制之一。
OBJECTIVE: To study the anti-virus and immune function of abiraterone hydrochloride in vivo and to explore the possible mechanism of abidomol hydrochloride in the treatment of viral myocarditis. Methods The mouse model of viral myocarditis was constructed by coxsackievirus B3 virus and treated with different concentrations of abildol hydrochloride for 7 days. After 30 days, the titer of myocarditis virus and some immune indexes were determined. Results The differences in the ㏒TCID50 between the three doses of abiraterone hydrochloride and the virus control group were all greater than 1, and the level of IFN was increased, the content of LPO was decreased, the activity of SOD was increased and the proliferation of mouse lymphocytes was promoted Reaction, enhance the killing activity of mouse NK cells, inhibit the release of myocardial enzyme LDH. Conclusion Arbidol hydrochloride has a significant therapeutic effect on viral myocarditis. Its mechanism of action is multifaceted. However, the regulation of immune function and the rapid elimination of oxygen free radicals in vivo may be one of the main mechanisms for the treatment of viral myocarditis.