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目的探讨T2DM肾病与Ins、HbA1c及肾功能的相关性。方法以健康体检者50例、T2DM无肾病组41例、T2DM肾病微量白蛋白尿组72例、T2DM肾病临床蛋白尿组58例作为研究对象,将各组Ins、HbA1c及肾功能等结果进行比较与分析。结果 T2DM肾病不同分期的各时段Ins与T2DM无肾病组比较差异均无统计学意义(P>0.05)。T2DM无肾病组、2个疾病组的FBG、HbA1c、TG与对照组比较差异均有统计学意义(P<0.05)。其他3组的UA、UREA、CREA、β2微球蛋白与T2DM肾病临床蛋白尿组比较差异均有统计学意义(P<0.05)。Spearman相关分析发现空腹Ins与各时段C肽、UA呈正相关(P<0.05),与HbA1c呈负相关(P<0.05);HbA1c与各时段Ins、各时段C肽、UA、CREA呈负相关(P<0.05)。结论血Ins、HbA1c及肾功能异常与T2DM肾病发生发展密切相关,降低HbA1c、CREA、UA及减少并发症对防治T2DM肾病有重要意义。
Objective To investigate the correlation between T2DM nephropathy and Ins, HbA1c and renal function. Methods 50 cases of healthy subjects, 41 cases of T2DM without nephropathy, 72 cases of T2DM nephropathy microalbuminuria group and 58 cases of T2DM nephropathy clinical proteinuria group were studied, and the results of Ins, HbA1c and renal function in each group were compared and analyse. Results There was no significant difference between Ins and T2DM without nephropathy in different stages of T2DM nephropathy (P> 0.05). There were significant differences in FBG, HbA1c, TG between two disease groups and T2DM without nephropathy (P <0.05). The other three groups of UA, UREA, CREA, β2 microglobulin and clinical proteinuria T2DM nephropathy group differences were statistically significant (P <0.05). Spearman correlation analysis showed that fasting Ins had a positive correlation with C-peptide and UA (P <0.05) and negatively correlated with HbA1c (P <0.05); HbA1c was negatively correlated with Ins, C peptide, UA and CREA P <0.05). Conclusions Blood Ins, HbA1c and renal dysfunction are closely related to the occurrence and development of T2DM nephropathy. To reduce HbA1c, CREA, UA and reduce complications is of great significance in preventing and treating T2DM nephropathy.