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探讨厄贝沙坦的降压效果,以及对高血压左心室肥厚的逆转和心功能影响。方法原发性高血压并左心室肥厚患者65例口服厄贝沙坦疗程20周,观察血压心率,多普勒超声心动图检测左心室厚度及心功能。结果治疗后收缩压与舒张压均有明显下降(P<0.01),而心率无明显下降(P>0.05):治疗后舒张期左室后壁厚度、舒张期室间隔厚度、左室质量指数均有显著下降(P<0.01):治疗后心排血量、舒张早期峰值流速/舒张晚期峰值流速、左室射血分数较治疗前有明显改善(P<0.01)。结论厄贝沙坦有良好的降压效应,而且能够逆转左心室肥厚,改善心功能,可以作高血压合并左心室肥厚患者首选治疗。
To investigate the antihypertensive effect of irbesartan and its effect on the reversal of left ventricular hypertrophy and cardiac function in hypertensive patients. Methods Sixty-five patients with essential hypertension and left ventricular hypertrophy were given oral irbesartan for 20 weeks. Blood pressure and heart rate were measured. Left ventricular thickness and cardiac function were measured by Doppler echocardiography. Results After treatment, the systolic and diastolic blood pressures were significantly decreased (P <0.01), while the heart rate was not significantly decreased (P> 0.05). The diastolic left ventricular posterior wall thickness, diastolic interventricular septum thickness and left ventricular mass index (P <0.01). The amount of cardiac output, peak early diastolic velocity / peak late diastolic velocity and left ventricular ejection fraction were significantly lower than those before treatment (P <0.01). Conclusion Irbesartan has a good antihypertensive effect, and can reverse left ventricular hypertrophy and improve cardiac function, hypertension can be used for the treatment of patients with left ventricular hypertrophy.