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目的探讨肝硬变患者血浆Ｄ二聚体及血小板聚集功能的临床意义．方法肝硬变患者５９例，正常对照组５１例．分别应用ＥＬＩＳＡ双抗体夹心法及光电比浊法测定其血浆Ｄ二聚体浓度及血小板聚集功能．结果肝硬变患者血Ｄ二聚体水平较对照组的高，而血小板聚集功能较对照组的低，差异均有显著性（Ｐ＜００１）；肝硬变肝功能Ａ，Ｂ，Ｃ级者较对照组血Ｄ二聚体水平逐渐增高，而血小板聚集功能逐渐下降（Ｐ＜００１）；肝硬变出血者血浆Ｄ二聚体水平较非出血的高（Ｐ＜００１），而血小板聚集功能却较非出血的低（Ｐ＜００１）；ＨＢｓＡｇ阳性组血浆Ｄ二聚体水平较ＨＢｓＡｇ阴性组的高（Ｐ＜００５），而血小板聚集功能在二者之间差异无显著性（Ｐ＞００５）．肝硬变患者Ｄ二聚体水平与血小板聚集功能呈直线负相关（ｒ＝－０７８，Ｐ＜００１）．结论肝硬变患者体内继发纤溶活性增强，其出血倾向与体内继发纤溶亢进及血小板聚集功能下降有关，血浆Ｄ二聚体水平及血小板聚集功能可望成为监测肝硬变患者肝功能的实验室指标．
Objective To investigate the clinical significance of plasma D-dimer and platelet aggregation in patients with cirrhosis. Methods 59 cases of cirrhosis patients, 51 cases of normal control group. Serum D-dimer and platelet aggregation were measured by ELISA double antibody sandwich method and photoelectric turbidimetry respectively. Results The serum levels of D-dimer in patients with cirrhosis were higher than those in the control group, while the platelet aggregation function was lower than that in the control group (P <001); liver cirrhosis with liver function A, B, C level than the control group, serum D dimer levels gradually increased, and platelet aggregation gradually decreased (P <0 01); cirrhosis with plasma D dimer level was higher than non-hemorrhage (P < 0 01), and platelet aggregation function was lower than non-hemorrhage (P <0 01); HBsAg-positive plasma D-dimer levels higher than HBsAg-negative group (P <0 05), while platelet aggregation There was no significant difference between them (P> 005). The level of D-dimer in patients with cirrhosis was negatively correlated with platelet aggregation (r = -0.78, P <0.01). Conclusions The secondary fibrinolytic activity of patients with cirrhosis is enhanced. The tendency of hemorrhage is related to the secondary hyperfibrinolysis and the decrease of platelet aggregation in vivo. The plasma D-dimer level and platelet aggregation function are expected to become the indicators of hepatic cirrhosis Functional laboratory indicators.