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目的了解深圳市龙岗区感染性腹泻病原谱的构成和流行特征,监测病原谱变迁趋势,为本地区感染腹泻防治提供科学依据。方法收集2010年-2014年龙岗区两家哨点医院腹泻患者粪便标本,按照卫生行业标准WS 287—2008、WS 271—2007和WS 289—2008进行沙门菌、致泻性大肠埃希菌等致病菌检测和诺如病毒等4种病毒核酸检测;对病原谱的时间分布、人群分布、血清型别构成进行统计学分析。结果 6 707份粪便标本中分离到1 361株致病菌,阳性率为20.29%;病原菌以致泻性大肠埃希菌、沙门菌和副溶血性弧菌为主;631份标本病毒核酸阳性,以诺如病毒和轮状病毒为主。结论致泻性大肠埃希菌、沙门菌、副溶血性弧菌、诺如病毒和轮状病毒是引起深圳市龙岗区感染性腹泻的主要病原体,病原谱已发生变迁,应主动加强监测和防控。
Objective To understand the composition and epidemiological characteristics of infectious spectrum of infectious diarrhea in Longgang District of Shenzhen City and to monitor the trend of pathogenic spectrum changes in order to provide a scientific basis for the prevention and treatment of diarrhea in this area. Methods Stool samples of diarrhea patients from two sentinel hospitals in Longgang District from 2010 to 2014 were collected and analyzed for Salmonella and diarrheal Escherichia coli according to the health industry standards WS 287-2008, WS 271-2007 and WS 289-2008 Pathogen detection and Norovirus detection of four kinds of virus nucleic acid; time distribution of the spectrum of the disease, the distribution of the population, the type of serum composition for statistical analysis. Results A total of 1 361 pathogenic bacteria were isolated from 6 707 stool specimens and the positive rate was 20.29%. Pathogenic bacteria were mainly diarrheal Escherichia coli, Salmonella and Vibrio parahaemolyticus. 631 samples were positive for nucleic acid, Norovirus and rotavirus dominated. Conclusions The pathogens such as Escherichia coli, Salmonella, Vibrio parahaemolyticus, Norovirus and rotavirus are the main pathogens causing infectious diarrhea in Longgang District of Shenzhen City. The pathogen spectrum has changed. Therefore, we should take the initiative to strengthen the surveillance and prevention control.