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目的探讨检测血清、尿β2-微球蛋白(β2MG)、血清胱抑素C(Cys-C)和全血糖化血红蛋白(HbA1c)浓度在糖尿病肾病(DN)诊治中的应用价值。方法测定45例单纯型糖尿病患者和40例糖尿病肾病患者血清、尿β2-MG、血清Cys-C、全血HbA1c浓度,并与40名健康人(对照组)进行比较。结果糖尿病组和糖尿病肾病组β2-MG、Cys-C和HbA1c均明显高于对照组,且糖尿病肾病组β2-MG、Cys-C和HbA1c均明显高于糖尿病组,差异均有统计学意义(P<0.05,P<0.01)。结论糖尿病患者β2-MG、Cys-C和HbA1c的浓度与糖尿病肾病密切相关。
Objective To investigate the diagnostic value of serum and urinary β2-microglobulin (β2MG), serum cystatin C (Cys-C) and total hemoglobin A1c (HbA1c) in the diagnosis and treatment of diabetic nephropathy (DN). Methods Serum and urinary β2-MG, serum Cys-C and whole blood HbA1c concentrations were measured in 45 patients with simple diabetes mellitus and 40 with diabetic nephropathy and compared with 40 healthy people (control group). Results The levels of β2-MG, Cys-C and HbA1c in diabetic group and diabetic nephropathy group were significantly higher than those in control group, and the levels of β2-MG, Cys-C and HbA1c in diabetic nephropathy group were significantly higher than those in diabetic group P <0.05, P <0.01). Conclusion The concentration of β2-MG, Cys-C and HbA1c in diabetic patients is closely related to diabetic nephropathy.