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[目的]探讨急性心肌梗死(AMI)合并 2 型糖尿病患者直接经皮冠脉介入(PCI)治疗的疗效及预后变化.[方法]在本院治疗的 AMI患者 142 例,其中合并 2 型糖尿病患者41 例(观察组),无 2 型糖尿病患者 101 例(对照组),比较两组手术情况及近远期主要不良心血管事件(MACE)发生情况.[结果]两组梗死部位、罪犯血管、手术时间及术后TIMI血流分级 2~3 级比例相比较差异均无显著性(P>0.05 );观察组多支病变比例及植入支架数明显高于对照组(P<0.05).观察组治疗后 1 个月心力衰竭发生率明显高于对照组(P<0.05);观察组治疗后24 个月心源性死亡、心力衰竭、和支架再狭窄发生率明显高于对照组(P0.05).The proportion of multiple vessel lesions and the number of stents implanted in the observation group were significantly higher than those in the con-trol group (P <0.05).The incidence of heart failure in the observation group was significantly higher than that in the control group (P <0.05)in one month after treatment (P <0.05).The incidence of failure and stent restenosis was significantly higher than that of control group (P <0.05).[Conclusion]The pathological changes of AMI patients with type 2 diabetes mellitus are more serious than those without diabetes mellitus,and the incidence of MACE in the near and long term is higher.