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钙通道阻滞剂(简称钙阻滞剂或钙拮抗剂、CB)是一类能选择性地阻滞Ca~(++)经细胞膜上的钙通道进入细胞内(即减少Sa~(++)内流)的药物。它的问世,为心血管疾病的防治增添了有力武器,是近十来年心血管药物治疗的重要进展之一。 CB除异搏停、硝苯吡啶、硫、氮卓酮外,目前归入CB的还有异搏停的同类药甲氧异搏停(Gallopmil、D600)、异搏静(Tiapamil),硝苯吡啶的同类药尼索的平(Nisoldipine)、尼卡的平(Nicardipine)、尼鲁的平(Niludipine)等;双环己哌啶(沛心达、Perhexiline);双苯
Calcium channel blockers (calcium blockers or calcium antagonists, CB) are a class of compounds that selectively block the passage of calcium through the cell membrane (ie, reduce the amount of Sa ~ (++ ) Influx) of the drug. Its advent of the cardiovascular disease prevention and treatment to add a powerful weapon, is one of the important advances in cardiovascular drug treatment in the past decade. In addition to CB withdrawal stop, nifedipine, sulfur, azozodone, currently included in the CB veterans with the same type of drug stop cardiopulmonary bypass (Gallopram, D600), Tachipan (Tiapamil), nifen Nisoldipine, Nicardipine, Niludipine, and the like of pyridine; Perhexiline; Diphenyl