Effects of electroacupuncture versus nimodipine on long-term potentiation and synaptophysin expressi

• 作 者: Dengming Wei Xuemin Jia Xiangx
• 机 构: Department of Pathology
• 出 处: 中国神经再生研究（英文版）
• 发表日期: 2004年期
• 关键词: vascular dementia electroacupuncture learning and memory ability long-term poten

The present study stimulated Baihui (DU 20) and Dazhui (DU 14) acupoints in a rat model of vascular dementia with electroacupuncture to investigate changes in long-term potentiation and synaptophysin expression in the hippocampus. The results revealed that synaptophysin expression in brain tissues was increased after electroacupuncture. After high-frequency stimulation, the population spike latencywas shortened and the excitatory postsynaptic potential slope and population spike amplitude were increased. In addition, cognitive function was enhanced, similar to the effects of intragastric perfusion of nimodipine. The results indicated that electroacupuncture at Baihui and Dazhui acupoints can improve learning and memory functions of a rat model of vascular dementia by promoting synaptophysinexpression, enhancing hippocampal synaptic plasticity and accelerating synaptic transmission.