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目的探讨甲亢对妊娠结局的影响及其之间的关系。方法回顾性分析山西省人民医院、山西医科大学附属第一医院、第二医院2009年10月-2011年10月期间住院分娩妊娠伴甲亢症患者63例,发病率为5.2‰,按照病情控制情况分为未控组(28例)和控制组(35例),随机选取同期正常妊娠30例为对照组,通过测量比较各组血清中的甲功5项和β2-m值,探讨甲亢对妊娠结局的影响及其之间的关系。结果⑴未控组血清TSH、FT3、FT4与控制组比较(P<0.01),变化明显,有统计学意义;⑵未控组T3、T4、β2-m测定值与正常对照组差异有显著性,有统计学意义;而控制组T3、T4、β2-m测定值与正常对照组无显著性差异,无统计学意义;⑶妊娠结局:未控组引产、早产、流产高于控制组(P<0.05)。⑷妊娠并发症:未控组妊娠甲状腺危象、甲亢性心脏病高于控制组(P<0.05)。结论妊娠合并甲亢的患者将甲状腺激素控制在理想范围有利于减少孕妇不良妊娠结局及并发症的发生。
Objective To investigate the effect of hyperthyroidism on pregnancy outcome and its relationship. Methods Retrospective analysis of Shanxi Provincial People’s Hospital, Shanxi Medical First Affiliated Hospital, Second Hospital, October 2009 -2011 in October period of pregnancy with hyperthyroidism 63 cases of pregnancy, the incidence rate of 5.2 ‰, according to the condition control The patients were divided into uncontrolled group (n = 28) and control group (n = 35). 30 normal pregnant women at the same period were randomly selected as the control group. The levels of thyroid function and β2- The impact of the outcome and the relationship between them. Results (1) The levels of TSH, FT3 and FT4 in the control group were significantly different from those in the control group (P <0.01), and the changes were statistically significant. (2) The values of T3, T4 and β2-m in the uncontrolled group were significantly different from those in the control group , There was statistical significance; while the control group T3, T4, β2-m measured values and the normal control group no significant difference, no statistically significant; ⑶ pregnancy outcome: uncontrolled group of induced labor, premature labor, abortion higher than the control group (P <0.05). ⑷ pregnancy complications: uncontrolled pregnancy thyroid crisis, hyperthyroidism heart disease was higher than the control group (P <0.05). Conclusions Patients with hyperthyroidism in pregnancy control thyroid hormone in the ideal range is conducive to reducing adverse pregnancy outcomes and complications of pregnant women.