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Bonders于1854年首次描述了生长于脉络膜Bruch膜上的drusen。在英语文献中过去称为胶状小体(colloid body)临床表现为眼底多个细小的黄白色带有闪光的视网膜下沉积物。病理组织学检查,视网膜色素上皮(RPE)下有嗜酸性物质堆积于Bruch膜内层。Drusen可出现于视功能完全正常的眼底,老年人中更多见,也可在一些眼底病(如:老年性黄斑变性、蛋黄样黄斑变性、脉络膜黑色素瘤、结晶样视网膜病变等)时发生,可与遗传有关。关于它的起因、
Bonders first described drusen grown on choroidal Bruch’s membrane in 1854. Colloquially referred to in the English literature as the clinical manifestations of the fundus multiple small yellow-white glittering subretinal deposits. Histopathological examination showed that there was accumulation of eosinophilic substance in the inner Bruch’s membrane under retinal pigment epithelium (RPE). Drusen may appear completely normal ocular fundus, more common in the elderly, but also in some fundus diseases (such as: age-related macular degeneration, pyodellosis, choroidal melanoma, crystalline retinal lesions, etc.) occur, Can be related to genetics. Regarding its cause,