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目的为了进一步验证阿德福韦酯对慢性乙型肝炎的抗病毒疗效。方法对34例慢性乙型肝炎患者用阿德福韦酯治疗作为观察组,另选33例慢性乙型肝炎患者予以一般护肝、降酶治疗作为对照组,观察治疗一年肝功能持续复常率及乙肝病毒复制情况。结果治疗一年观察组肝功能持续复常率与对照组相比差异有统计学意义,观察组HBVD-NA转阴率与对照组比较差异有统计学意义。结论阿德福韦酯对乙肝病毒复制有显著抑制作用,能明显改善肝功能。
Aim To further verify the antiviral effect of adefovir dipivoxil on chronic hepatitis B. Methods Forty-three patients with chronic hepatitis B were treated with adefovir dipivoxil as observation group and 33 patients with chronic hepatitis B were treated with general liver protection and enzyme-lowering therapy as control group. One year of continuous liver function recovery Rate and hepatitis B virus replication. Results One year after treatment, the sustained rate of abnormal liver function in the observation group was significantly different from that in the control group. The negative rate of HBVD-NA in the observation group was significantly different from that in the control group. Conclusion Adefovir dipivoxil has a significant inhibitory effect on hepatitis B virus replication and can significantly improve liver function.