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四例患溃疡性结肠炎男性青年长期(3—6年)断续用磺胺柳酸吡啶治疗致精子总数及话动力降低,异型精子百分率升高并发生不育。他们的爱人检查未发现任何不孕的原因。所有患者停服该药后,精子总数及活动力迅速恢复正常,异型精子百分率降低,同时其中三人的爱人四次怀孕。有二例患者因结肠炎复发再用该药时,精子急剧发生退行性变。各患者睾丸大小及各项内分泌化验值正常。抗精子抗体均未测得。一例单纯用磺胺柳酸吡啶时,睾丸活组织检查示曲细精管有精子
Four cases of young men suffering from ulcerative colitis, long-term (3-6 years) intermittent treatment with pyridine sulfonamide caused a decrease in the total number of sperm and motility, dysfunctional sperm percentage increased and infertility. Their lover did not find any reason for infertility. All patients stopped taking the drug, the total number of sperm and motor activity quickly returned to normal, reduced percentage of dysplastic sperm, while three of my lover four pregnancies. Two patients relapsed because of colitis recurrence of the drug, the rapid degeneration of sperm. Testicular size and various endocrine tests were normal in all patients. Anti-sperm antibodies were not measured. A case of simple sulfanilamide pyridine, testicular biopsy shows seminiferous tubules have sperm