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最近证明,对真菌细胞壁物质有抑制作用的两类化合物为几丁质合成抑制剂nikk-omycin类、多氧菌素类,β-葡聚糖抑制剂papulacandin B、aculeacin A和echinoc-andin B,对医学上重要真菌均有明显的作用,有可能成为治疗剂。用多氧菌素D处理在细胞壁合成中由几丁质重要作用的厌酷球孢子菌(Coccidiodes immitis)和Wangie-lla dermatitidis,结果导致异常型或溶菌。同样,几丁质合成酶抑制剂多氧菌素D,对几丁质起整合作用的白色念珠菌(Candidaalbican)也有作用。虽然菌丝型侵入患病组织的能力强于酵母型,而且有较多的几丁质和较强聚合物合成能力,但是比其它两态真菌的细胞壁所含几丁质少得多。而且核苷肽类化合物,只能少量透过胞质基质膜;同
Recently, two classes of compounds that inhibit fungal cell wall material have been identified as the nikk-omycin chitin synthesis inhibitors, the polyoxins, the beta-glucan inhibitors papulacandin B, aculeacin A and echinoc-inin B, Significant effect on medically important fungi, may become a therapeutic agent. Treatment of Coccidiodes immitis and Wangie-lla dermatitidis with chitin important in cell wall synthesis with polyoxygenin D resulted in abnormal or bacteriolysis. Similarly, chitin synthase inhibitor polyoxygenin D also has an effect on Candida albican, which has an integrin effect on chitin. Although mycelium invades diseased tissue more strongly than yeast and has more chitin and stronger polymer synthesis capacity, it is much less chitin-containing than the cell walls of other two-fungal species. And nucleosides peptide compounds, only a small amount through the cytoplasmic membrane; the same