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作者报道一项双盲随机研究,中至重度寻常痤疮患者200例(14～30岁),分别接受口服红霉素碱(100例)或口服四环素(100例),治疗12周。疗程结束时,症状明显好转或好转的患者红霉素组有77%,四环素组有89%,两组均有常见的副作用即胃肠症状(恶心和腹泻),红霉素组有一例出现皮疹。四环素组有1例发生阴道念珠菌病和1例(男性)发生假性脑瘤症状。作者由此得出结论:口服红霉素和四环素治疗炎性寻常痤疮的疗效和耐受性都相同。
The authors report a double-blind, randomized study of 200 patients (14-30 years) with moderate to severe acne who received oral erythromycin (100) or oral tetracycline (100) orally for 12 weeks. 77% of patients in the erythromycin group and 89% of the patients in the tetracycline group had marked improvement or improvement at the end of the course of treatment, both of which had common gastrointestinal symptoms (nausea and diarrhea) and one in the erythromycin group . One case of tetracycline group had vaginal candidiasis and one case (male) of pseudo-brain tumor. The authors concluded that oral erythromycin and tetracycline for the treatment of acne vulgaris efficacy and tolerance are the same.