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研究了以2-羟基-4-甲氧基苯甲醛和3-氨基吡啶为原料,微波固相反应合成新型席夫碱衍生物——标题化合物的方法。当2-羟基-4-甲氧基苯甲醛与3-氨基吡啶物质的量比为1.5∶1、反应时间为8 min、微波功率为920 W时,反应产率可达94%以上。用IR、1HNMR、元素分析和X-射线单晶衍射法表征了产物结构。该化合物属正交晶系,空间群为P212121,a=3.940(2),b=10.506(5),c=26.811(14),Dc=1.366 Mg/m3,Z=4,V=1 109.8(10)3,μ=0.094mm-1,R1=0.066 5,wR2=0.106 9。
A novel method for the synthesis of novel Schiff base derivatives - 2-hydroxy-4-methoxybenzaldehyde and 3-aminopyridine by microwave solid-phase reaction was studied. When the molar ratio of 2-hydroxy-4-methoxybenzaldehyde to 3-aminopyridine was 1.5:1, the reaction time was 8 min and the microwave power was 920 W, the yield of the reaction reached 94%. The product structure was characterized by IR, 1HNMR, elemental analysis and X-ray single crystal diffractometry. The compound belongs to the orthorhombic system with space group P212121, a = 3.940 (2) , b = 10.506 (5) , c = 26.811 14, Dc = 1.366 Mg / m3, Z = 1 109.8 (10) 3, μ = 0.094 mm-1, R1 = 0.066 5, wR2 = 0.106 9.