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根据近20年的流行病学调查结果提示,通过比较北京和广州人群的血脂成分,来了解两地区人群血脂组成的差异,为两地区心血管疾病不同发病率的原因寻找线索。自北京和广州现场采集高脂血症及对照人群的血清样本,以酶法或免疫透射比浊法测定,总胆固醇、甘油三酯、高密度脂蛋白胆固醇(HDLC)、HDL2C、HDL3C、低密度脂蛋白胆固醇(LDLC)、载脂蛋白AI、AⅥ及B,并分组进行统计学显著性测验。结果发现两地区的高脂血症患者都以高甘油三酯血症为主,高脂血症组的HDLC水平显著低于对照组,尤以HDLC亚类水平低。高脂血症组载脂蛋白B和AⅥ高于对照组,而载脂蛋白AI无差异。北京与广州两现场
According to the epidemiological survey results in recent 20 years, it is suggested that the difference of blood lipid composition between the two populations can be obtained by comparing the blood lipid components of Beijing and Guangzhou populations, so as to find clues for the different incidence of cardiovascular diseases in the two regions. Serum samples of hyperlipidemia and control subjects were collected from Beijing and Guangzhou. The levels of total cholesterol, triglyceride, high density lipoprotein cholesterol (HDLC), HDL2C, HDL3C, low density Lipoprotein cholesterol (LDLC), apolipoprotein AI, A Ⅵ, and B were measured and grouped for statistical significance tests. The results showed that hyperlipidemia patients in both regions mainly hypertriglyceridemia, HDLC levels in hyperlipidemia group was significantly lower than the control group, especially in HDLC subclass level is low. The levels of apolipoproteins B and A VI in hyperlipidemia group were higher than those in control group, while there was no difference in apolipoprotein AI. Beijing and Guangzhou two live