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目的：检测ｃｙｃｌｉｎ Ｄ１基因在鼻咽癌（ａｓｏｐｈａｒｙｎｇｅａｌ ｃａｒｃｉｎｏｍａ， ＮＰＣ）细胞中的扩增情况，探讨ｃｙｃｌｉｎＤ１基因在ＮＰＣ发生及发展中的作用。方法：应用间期Ｍｉｃｒｏ－ＦＩＳＨ技术。结果： ８３例ＮＰＣ病例可见２３例（占 ２７．７１％）出现ｃｙｃｌｉｎ Ｄ１扩增；其中 Ｉ、Ⅱ期病例扩增的有５例，Ⅲ、Ⅳ期病例扩增的有１８例； ２３例扩增中１６例（６９．５６％）伴有颈淋巴结转移。结论：ｃｙｃｌｉｎ Ｄ１扩增与 ＮＰＣ的中晚期发展可能有一定关系，并与颈淋巴结转移呈正相关。
Objective: To detect the amplification of cyclin D1 gene in nasopharyngeal carcinoma (NPC) cells and explore the role of cyclinD1 gene in the occurrence and development of NPC. Methods: Interphase Micro-FISH technique was applied. RESULTS: A total of 23 cases (27.71%) of NPC were found to have cyclin D1 amplification; 5 of them were expanded in stage I and II cases, and 18 cases were expanded in stages III and IV; 23 cases were expanded. Zengzhong 16 cases (69.56%) were associated with cervical lymph node metastasis. Conclusion: The amplification of cyclin D1 may be related to the mid-late development of NPC, and it is positively correlated with cervical lymph node metastasis.