吡喹酮透皮给药治疗动物血吸虫病的最低有效剂量、血浓及毒性观察

• 作 者: 彭惠玲 鲁敏 邓爱群 任润香 易志辉 冯冬初 涂祖武 王在华 严寄雄 周美娟
• 机 构: 湖北省血吸虫病防治研究所,湖北省血吸虫病防治研究所,湖北省血吸虫病防治研究所,湖北省血吸虫病防治研究所,湖北省血吸虫病防治研究所,湖北省血吸虫病防治研究所,湖北省血吸虫病防治研究所,湖北省血吸虫病防治
• 出 处: 湖北预防医学杂志
• 发表日期: 1991年02期
• 关键词: 吡喹酮 透皮给药 血吸虫病 吡喹酮透皮剂 最低有效剂量 血浓 急性毒性 器质性病 等剂量 涂药

本文叙述了吡喹酮透皮给药治疗血吸虫病的最低有效剂量:消旋吡喹酮为100mg/kg,左旋吡喹酮为 50mg/kg;应用高压液相色谱法测定家兔透皮给药后血清药浓,同等剂量,相同时间情况下,透皮给药者的血浓明显高于口服途径给药。病理学观察表明,吡喹酮透皮给药大剂量对肝细胞有直接损害作用,相同剂量情况下,口服途径对肝脏的毒性作用要比透皮给药者大,致死率高。涂药部位皮肤观察未发现明显的器质性病变。

This article describes the lowest effective dose of praziquantel for the treatment of schistosomiasis: 100 mg/kg of racemic praziquantel and 50 mg/kg of levopraziquantel; rabbits were tested for transdermal delivery using high pressure liquid chromatography. After the serum drug concentration, the same dose, the same time, the blood concentration of transdermal drug delivery was significantly higher than the oral route. Pathological observations showed that large doses of transdermal praziquantel had direct damage to hepatocytes. Under the same doses, oral administration had a heavier toxic effect on the liver than transdermal ones, with a high fatality rate. No obvious organic lesions were observed in the skin of the applicator.