Possible role of polyamines in gastric mucus synthesis inhibited by cigarette smoke exposure and its

• 作 者: 马莉 周业金 曹之宪
• 机 构: Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, Hong Kong, China,Depar
• 出 处: Acta Pharmacologica Sinica
• 发表日期: 1999年07期
• 关键词: cigarette smoke extracts inhibited healing exposure smoking accelerate ornithine

AIM: Cigarette smoking was shown to delay gastric ulcer healingand reduce mucus synthesis, which is important for gastricmucosal protection and healing. Since polyamines had beenshown to accelerate ulcer healing, we hypothesized that cigarettesmoking reduced mucus synthesis through its interference with thepolyamine pathway. METHODS: In vitro, mucus synthesis

AIM: Cigarette smoking was shown to delay gastric ulcer healing and reduce mucus synthesis, which is important for gastric mucosal protection and healing. Since polyamines had been shown to accelerate ulcer healing, we hypothesized that the cigarettes moking reduced mucus synthesis through its interference with the polyamine pathway. METHODS: In vitro, mucus synthesis