论文部分内容阅读
外科医师在手术时最容易通过血液接触感染血源性疾病.已证实在出血及长时间手术中,血液接触是常见的方式.血液传播的疾病包括人类免疫缺陷性疾病(HIV),乙型肝炎病毒(HBV)和其他一些引起肝炎的病源体.由于最近对病源体的克隆以及特殊检验的开展,已认识到丙型肝炎病毒(HCV)感染是引起输血后或血源性肝炎的主要原因.此型肝炎常导致肝硬化和肝细胞癌.目前.对这一血源性病源体的预防措施尚在研究中.尽管HCV抗体阳性率在自愿献血中为0.42～1.4%,但在外科病人中的感染率仍不清楚.本研究的目的是了解外科病人中HCV的感染率以及确定与HCV抗体阳性的相关因素.作者自1991年4月至1992年5月,共检查了789例病人,平均年龄58.1±14.2岁,男性469例,其中胃肠道疾病202例,肝胆道疾病141例,门脉高压65例,血管疾患188例,肺疾患107例,其他疾病29例.应用Ortho ELISA方法进行检测.结果显示789例被检测的病人中HCV抗体阳性者为129例(16.3%),其阳性率比一般日本人高得多;肝胆道疾病及门脉高压者较其他疾患阳性率高,前者阳性率为94/206,即45.6%,而其它疾患的阳性率为35/583,即6%;两者P<0.0001.50岁以上者较年轻者发病率高,前者阳性率为118/578, 即20.4%,后者阳性率为11/211,即5.3%;两者P<0.0001.作者把有输血史,外科手术史,肝功
Surgeons are most likely to have blood-borne blood-borne diseases during surgery, and blood contact has been shown to be common in both hemorrhage and long-term surgeries. Blood-borne diseases include human immunodeficiency disease (HIV), hepatitis B Viruses (HBV) and other etiological agents that cause hepatitis.Because of the recent cloning of pathogens and the development of special tests, it has been recognized that hepatitis C virus (HCV) infection is a major cause of posttransfusion or hematogenous hepatitis. This type of hepatitis often leads to cirrhosis and hepatocellular carcinoma.Prevention of this blood-borne pathogen is currently under study.Although HCV antibody-positive rates range from 0.42 to 1.4% of voluntary blood donations, in surgical patients Of the infection rate is still unclear.The purpose of this study is to understand the surgical patients HCV infection and to determine the relevant factors and HCV antibody positive.From April 1991 to May 1992, a total of 789 patients were examined, the average The age of 58.1 ± 14.2 years, 469 males, including 202 cases of gastrointestinal diseases, liver and biliary diseases in 141 cases, 65 cases of portal hypertension in 188 cases of vascular disease in 107 cases, other diseases in 29. Ortho ELISA method Test results The positive rate of HCV antibodies in 789 patients was 129 cases (16.3%), which was much higher than that in Japanese. The positive rates of hepatobiliary disease and portal hypertension were higher than those of other diseases, the positive rate was 94/206, or 45.6%, and other diseases, the positive rate was 35/583, or 6%; both P <0.0001.50 years old and older than the high incidence of the former positive rate of 118/578, or 20.4 %, The latter positive rate was 11/211, or 5.3%; both P <0.0001. The authors have a history of blood transfusion, surgical history, liver function