西地那非和咯利普兰对离体人和猴海绵体肾上腺能反应机制的作用

• 作 者: 冷新
• 机 构: 江苏省昆山市第一人民医院泌尿外科 215300
• 出 处: 中国男科学杂志
• 发表日期: 2007年11期
• 关键词: 咯利普兰 海绵体 西地那非 海绵体平滑肌 异丙肾上腺素 收缩反应 猴子 冲洗器 浓度 去甲肾上腺素

为评估和比较两种磷酸二酯酶抑制剂西地那非和咯利普兰对于人及猴海绵体平滑肌肾上腺能收缩反应的效果,Lau LC等人进行了一项研究,研究者从性别重塑手术(变性手术)中获得人类阴茎,离体的人和猴子的海绵体被悬挂于等长张力实验所用的组织冲洗器中。观察两种药物对实验所用的离体猴子和人海绵体所起的作用以及对于人海绵体的神经原性收缩。结果显示,西地那非和咯利普兰都能诱导用去甲肾上腺素预处理过的离体人和猴海绵体产生浓度依赖性舒张。IC50值,由逆转被硝酸甘油,异丙肾上腺素对猴子海绵体的反

To assess and compare the effects of two phosphodiesterase inhibitors sildenafil and rolipram on human and monkey sponge smooth muscle adrenal contractile responses, Lau LC et al. Conducted a study of gender remodeling The cavernous body of human penis, isolated human and monkey in surgery (degenerative surgery) was suspended in a tissue irrigator used for isometric tension experiments. The effects of the two drugs on the isolated monkeys and human sponges used in the experiment and the neurogenic contraction to human sponges were observed. The results showed that sildenafil and rolipram both induced concentration-dependent relaxation in isolated human and monkey sponges pretreated with norepinephrine. The IC50 value, by reversal of nitroglycerin, isoproterenol anti-monkey sponge