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目的对深圳市甲型H1N1流感疫苗接种不良反应的发生情况进行分析,为免疫策略的制定提供依据。方法从国家儿童预防接种信息管理系统中收集深圳市的疑似预防接种异常反应个案信息中的不良反应个案,使用SPSS17.0进行数据分析。结果 2009-10-31/2010-04-30,深圳市甲流疫苗接种累计报告不良反应210例,报告发生率为3.29/万,<3岁年龄组的不良反应发生率明显高于其他年龄组,而流动人口的不良反应发生率要明显低于其他职业。病例大多数为一般反应,多为24 h内出现症状,并以发热和过敏反应为主要表现。绝大多数病例预后良好。结论深圳市甲流疫苗接种后产生的不良反应以轻症为主,接种安全性较高。接种后发生的严重异常反应主要为严重的过敏反应,建议今后疫苗生产企业应对疫苗的成分进行更清楚的标识,以避免严重过敏反应的发生。经过一年的跟踪,接种甲流疫苗无神经系统的不良反应发生。
Objective To analyze the incidence of adverse reactions of influenza A (H1N1) vaccination in Shenzhen and provide evidence for the development of immunization strategies. Methods A total of 7 cases of adverse reactions in the case information of suspected immunization in Shenzhen were collected from the National Children’s Vaccination Information Management System and SPSS17.0 was used to analyze the data. Results 2009-10-31 / 2010-04-30, Shenzhen reported a total of 210 cases of adverse reactions reported vaccination, the report was 3.29 / million, <3-year-old adverse reaction rate was significantly higher than other age groups , While the incidence of adverse reactions in floating population should be significantly lower than other occupations. The majority of cases were general reactions, mostly within 24 h symptoms, and fever and allergic reactions as the main performance. The vast majority of cases with good prognosis. Conclusions The main adverse reaction after the vaccination in Shenzhen is mainly mild and the vaccination is safe. Severe anaphylaxis after inoculation is mainly a serious allergic reaction, suggesting that vaccine manufacturers in the future to deal with the vaccine ingredients more clearly identified in order to avoid the occurrence of serious allergic reactions. After a year of follow-up, vaccination of a flow of vaccine without adverse reactions to the nervous system.