High-frequency and brief-pulse stimulation pulses terminate cortical electrical stimulation-induced

• 作 者: Zhi-wei Ren Yong-jie Li Tao Yu Duan-yu Ni Guo-jun Zhang Wei Du Yuan-yuan Piao Xiao-xia Zhou
• 机 构: Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University,
• 出 处: Neural Regeneration Research
• 发表日期: 2017年06期
• 关键词: stimulation brief cortical epilepsy likely seizure conclusion refractory unclear

Brief-pulse stimulation at 50 Hz has been shown to terminate afterdischarges observed in epilepsy patients. However, the optimal pulse stimulation parameters for terminating cortical electrical stimulation-induced afterdischarges remain unclear. In the present study, we examined the effects of different brief-pulse stimulation frequencies(5, 50 and 100 Hz) on cortical electrical stimulation-induced afterdischarges in 10 patients with refractory epilepsy. Results demonstrated that brief-pulse stimulation could terminate cortical electrical stimulation-induced afterdischarges in refractory epilepsy patients. In conclusion,(1) a brief-pulse stimulation was more effective when the afterdischarge did not extend to the surrounding brain area.(2) A higher brief-pulse stimulation frequency(especially 100 Hz) was more likely to terminate an afterdischarge.(3) A low current intensity of brief-pulse stimulation was more likely to terminate an afterdischarge.

Brief-pulse stimulation at 50 Hz has been shown to terminate after discharges observed in epilepsy patients. However, the optimal pulse stimulation parameters for terminating cortical electrical stimulation-induced afterdischarges remain unclear. In the present study, we examined the effects of different brief-pulse stimulation frequencies (5, 50 and 100 Hz) on cortical electrical stimulation-induced afterdischarges in 10 patients with refractory epilepsy. Results conclusion that brief-pulse stimulation could terminate cortical electrical stimulation-induced after discharge in refractory epilepsy patients. In conclusion, (1) A brief-pulse stimulation was more effective when the afterdischarge did not extend to the surrounding brain area. (2) A higher brief-pulse stimulation frequency (especially 100 Hz) was more likely to terminate an afterdischarge. (3) A low current intensity of brief-pulse stimulation was more likely to terminate an afterdischarge.