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慢性尿毒症病人血小板计数为1.79±0.76×10~5/ml,而正常为2.66±0.65×10~5/ml(P<0.01)。以固定浓度二磷酸腺苷(ADP)诱导病人血小板聚集率为29.22±19.9％,正常人则为71.64±13.50％(P<0.001)。病人血小板~(14)C-5HT摄取率为54.24±20.90％,正常人为71.52±11.17％(P<0.05);~(14)C-5HT释放率为18.62±17.82％,而正常人为44.94±11.01％(P<0.001)。以上结果表明,慢性尿毒症病人血小板计数、血小板聚集和释放5HT的功能均较正常人明显减低,推测是病人伴有出血倾向的主要原因。
Chronic uremia patients platelet count was 1.79 ± 0.76 × 10 ~ 5 / ml, while the normal was 2.66 ± 0.65 × 10 ~ 5 / ml (P <0.01). The platelet aggregation rate induced by fixed concentration of adenosine diphosphate (ADP) was 29.22 ± 19.9% in patients and 71.64 ± 13.50% in normal subjects (P <0.001). The uptake rate of ~ (14) C-5HT was 54.24 ± 20.90% in patients and 71.52 ± 11.17% in normal controls (P <0.05). The release rate of ~ (14) C-5HT was 18.62 ± 17.82%, while the normal rate was 44.94 ± 11.01 % (P <0.001). The above results show that patients with chronic uremia platelet count, platelet aggregation and the release of 5HT function were significantly lower than normal, presumably the main reason for bleeding associated with the patient.