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纤维结合素纤维结合素(Fibronectln,简写Fn)是一族结构和免疫性质相似的高分子量糖蛋白.1948年首先由Morrison等所报告.由于它在冷却时沉淀,故当时被命名为“血浆冷沉淀球蛋白”.它不能被凝血酶凝结,比纤维蛋白元有更大的电泳迁移率和沉淀系数.此后,它还曾被使用过下列名称:大分子外部转运敏感蛋白(LETS)、可溶性成纤维细胞抗原(SF-抗原)、细胞表面蛋白(CSP)、细胞粘附因子(CAF)、调理素蛋白、细胞扩散因子等.1976年,Kuusela命名此类蛋白为纤维结合素.Fn存在于细胞外液(主要是血浆)、结缔组织、细胞表面以及大多数基底膜上.血浆Fn可能的来源是血管内皮细胞.组织Fn,除了成纤维细胞之外,许旺氏细胞及某些上皮细胞(包括从肿瘤细胞衍化来
Fibronectln (abbreviated Fn) is a family of high-molecular-weight glycoproteins with similar structures and immunities, first reported by Morrison et al in 1948. Since it precipitated on cooling, it was then named “plasma cold Precipitated globulin. ”It can not be coagulated by thrombin, has a greater electrophoretic mobility and precipitation coefficient than fibrin, and has since been used with the following names: macromolecule transporter-sensitive protein (LETS), soluble Fibroblast Antigen (SF-antigen), Cell Surface Protein (CSP), Cell Adhesion Factor (CAF), Opsonin, Cell Diffusion Factor, etc. Kuusela names such proteins fibronectin in 1976. Fn is present in Extracellular fluid (mainly plasma), connective tissue, cell surface, and most of the basement membrane.Possible source of plasma Fn is vascular endothelial cells.Fan, in addition to fibroblasts, Schwann cells and some epithelial cells (Including derived from tumor cells