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胆脂瘤型中耳炎的发病原因至今尚不明确；其病理组织学特点是中耳腔内存在着表皮角化的复层鳞状上皮。一般认为，胆脂瘤上皮是以因过度增生的角化细胞失调而导致中耳正常粘膜的损伤为特点的。本文对20例本病患者的胆脂瘤上皮应用免疫组织化学方法，观察表皮生长因子受体（EGF－
The pathogenesis of cholesteatoma otitis media is still not clear; the histopathological features of the middle ear cavity is the existence of epidermal keratinized stratified squamous epithelium. It is generally believed that cholesteatoma epithelium is characterized by damage to the normal mucosa of the middle ear caused by dysregulation of hyperproliferative keratinocytes. In this paper, 20 cases of patients with cholesteatoma epithelial application of immunohistochemical methods to observe the epidermal growth factor receptor (EGF-