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目的 探讨食管癌（ＥＣ） 患者红细胞（ＲＢＣ） 免疫功能的改变。方法 选择１２５ 例高发区ＥＣ患者、５５ 名健康志愿者。比较患者组与常人组ＲＢＣ免疫功能；患者组以ＴＮＭ 分期、围术期分层比较。结果 患者ＲＢＣＣ３ｂ 受体花环率降低（ Ｐ ＜ ０ ．０５）；ＲＢＣ 免疫复合物花环率升高（ Ｐ ＜ ０．０５） ；血清ＲＢＣ免疫抑制因子含量增多（ Ｐ＜ ０．０５） ；ＲＢＣ免疫促进因子含量降低（ Ｐ＜ ０ ．０５） 。患者肿瘤ＲＢＣ花环，如直向肿瘤ＲＢＣ花环率、促肿瘤ＲＢＣ花环率、协同肿瘤ＲＢＣ 花环率、自然肿瘤ＲＢＣ花环试验均有降低（ Ｐ＜０ ．０５）。结论 ＥＣ患者ＲＢＣ免疫功能低下，其受抑程度与患者病变的早晚有关；手术可加剧这种改变。
Objective To investigate the changes of immune function of erythrocyte (RBC) in patients with esophageal cancer (EC). Methods 125 patients with EC in high incidence area and 55 healthy volunteers were selected. The immune function of RBC in patients and control groups was compared. TNM stage and perioperative stage were compared among the patients. Results The rosette rate of RBCC3b receptor decreased (P <0.05), the rate of rosette of RBC immune complex increased (P <0.05), the content of RBC immunosuppressive factor increased (P <0.05) Factor content decreased (P <0 .05). RBC rosette, such as RBC rosette rate, tumor RBC rosette rate, synergistic tumor RBC rosette rate, and natural tumor RBC rosette test were all decreased (P <0.05). Conclusions The immune function of RBC in patients with EC is low, and the degree of suppression is related to the lesion in patients with EC. Operation can exacerbate this change.