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Damage-regulated autophagy modulator gene (DRAM) was first identified by Crighton et al.in 2006 when they treated Saos-2 cells with doxycycline and adriamycin after p53 induction and analyzed gene expression by using microarray technology [1].The DRAM gene locates on the human chromosomal 12q23.2 [2] and encodes a 238 amino acid lysosomal protein whose role in autophagy is phylogenetically conserved.As a direct target of P53,DRAM is a critical modulator in p53-induced autophagy and programed cell death [3].Nevertheless,the exact mechanism through which DRAM modulates autophagy has not been clarified.Sequence analysis predicted that the DRAM protein contains six transmembrane domains and several other highly conversed domains [1],therefore understanding the exact role of each domain of DRAM in autophagy may help to clarify the exact mechanism.