论文部分内容阅读
Macrophages are the key cells in metabolic syndrome and are also a risk factor for metabolic disease.Macrophages have different functions and transcriptional profiles,but all are required for maintaining homeostasis.It is well known that macrophages play a key role in inflammation and early atherogenesis,and are present in two phenotypes:pro-inflammatory (M1) and antiinflammatory (M2).Osteoclast stimulatory transmembrane protein (oc-stamp) is a multiple-pass transmembrane protein;however,its function remains unclear.In this study,we explored the role of oc-stamp in macrophages physiology.The results showed that oc-stamp was notably decreased under LPS and IFN-γ stimulation,while it was increased with IL-4 treatment.Furthermore,oc-stamp induced a phenotypic switch in macrophage polarization,suppressing the M1 pro-inflammatory state in the overexpression group,and promoting the M1 pro-inflammatory state in the knockdown group.Further study revealed that oc-stamp regulated macrophage polarization possibly via STAT6.Taken together,our results are the first to demonstrate that oc-stamp may play an important role in macrophage polarization and inhibit the M1 pro-inflammatory state.