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过去几年癌症患者发生溶血性尿毒综合征已有描述,80%死亡率发生在诊断后12月内。葡萄球菌蛋白A(SPA)是致病葡萄球菌的细胞壁部分,它非特异性地结合IgG分子的FC部分,并优先结合IgG的复合型。近来对晚期肿瘤患者用SPA免疫灌法的研究显示此法能导致免疫复合物(IC)从循环中部分或完全清除,本文系测定癌相关溶血性尿毒综合征(C-HUS)患与SPA免疫灌注的临床功效。作者研究11例腺癌,女性5例,男性6例,年龄
Hemolytic uremic syndrome has been described in cancer patients over the past few years, with 80% of deaths occurring within 12 months of diagnosis. Staphylococcal protein A (SPA), a cell wall part of staphylococcus aureus, binds nonspecifically to the FC portion of IgG molecules and preferentially binds IgG complexed forms. A recent study of SPA immunosurvection in patients with advanced cancer showed that this method can result in the partial or complete clearance of immune complexes (ICs) from the circulation. This article was designed to determine the presence of C-HUS in patients with cancer-associated immunosuppression Perfusion of clinical efficacy. The authors studied 11 cases of adenocarcinoma, 5 women, 6 males, age