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基质金属蛋白酶(MMPs)是含有9种酶蛋白分子的家族,可以导致基质膜和细胞间质成分破坏与降解,在恶性肿瘤的侵袭与转移中发挥重要作用。近年来研究证明MMP-2在肿瘤的浸润和转移中起了关键作用〔1〕。本研究拟探讨MMP-2与结直肠癌发生、发展、浸润和转移的关系。1材料与方法1.1材料选取唐山市协和医院2005～2007年间资料齐全的结直肠癌标本存档蜡块53例,正常人黏膜组织37例;年龄41～75(平均56)岁;以上标本均经病理证实。患者术前均未
Matrix metalloproteinases (MMPs), a family of 9 enzyme protein molecules, can cause the destruction and degradation of matrix membrane and interstitial components, and play an important role in the invasion and metastasis of malignant tumors. In recent years, studies have shown that MMP-2 plays a key role in tumor invasion and metastasis [1]. This study was to investigate the relationship between MMP-2 and the occurrence, development, invasion and metastasis of colorectal cancer. 1 Materials and Methods 1.1 Selection of materials Tangshan City Union Hospital from 2005 to 2007 complete colorectal cancer specimens archived 53 cases of wax, normal mucosa in 37 cases; aged 41 to 75 (average 56) years of age; the above specimens were pathologically Confirmed. Patients were not before surgery