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目的:探讨ER、PR、P53在子宫内膜癌(EC)中的表达及其临床意义。方法:采集2007年1月-2011年12月57例子宫内膜癌病例资料,应用免疫组织化学法检测ER、PR和P53的表达情况并进行统计学分析。结果:ER、PR在子宫内膜癌的组织学分级表达有统计学意义(P<0.05),ER、PR的阳性表达率随着组织学分级的增高而逐渐降低。P53的阳性表达与子宫内膜癌的组织分化程度、肌层浸润及有无淋巴结转移具有统计学意义(P<0.05),不同组织学类型中表达无统计学差异。结论:子宫内膜癌组织中ER、PR、P53的表达与组织学分级密切相关,其测定是评估(EC)预后的重要指标,对于指导临床治疗具有重要意义。
Objective: To investigate the expression and clinical significance of ER, PR and P53 in endometrial carcinoma (EC). Methods: The data of 57 cases of endometrial carcinoma from January 2007 to December 2011 were collected. The expression of ER, PR and P53 were detected by immunohistochemistry and analyzed statistically. Results: The histological grade of ER and PR in endometrial carcinoma was statistically significant (P <0.05). The positive rate of ER and PR decreased gradually with the increase of histological grade. The positive expression of P53 and histological differentiation of endometrial carcinoma, myometrial invasion and lymph node metastasis was statistically significant (P <0.05), there was no significant difference in different histological types. Conclusion: The expression of ER, PR and P53 in endometrial carcinoma is closely related to the histological grade. The determination of ER, PR and P53 in endometrial carcinoma is an important index to evaluate the prognosis of EC. It is of great significance for clinical treatment.