论文部分内容阅读
目的探讨癌症患者血清透明质酸(HA)、Ⅳ型胶原(Ⅳ-C)及层粘连蛋白(LN)的水平变化及与恶性肿瘤病变的关系。方法采用放射免疫法测定303例癌症患者、39例一般疾病患者及33例健康志愿者血清HA、Ⅳ-C和LN水平。结果癌症患者血清HA、Ⅳ-C和LN水平显著增高,较正常对照组、一般疾病组差异有统计学意义(P<0.05),一般疾病组与正常对照组各指标之间差异无统计学意义(P>0.05)。结论血清HA、Ⅳ-C和LN水平变化对癌症患者诊断、病情转归及预后判断有参考价值。
Objective To investigate the changes of the serum levels of hyaluronan (HA), type Ⅳ collagen (Ⅳ-C) and laminin (LN) in cancer patients and their relationship with the pathological changes of malignant tumor. Methods The serum levels of HA, Ⅳ-C and LN in 303 cancer patients, 39 patients with general diseases and 33 healthy volunteers were determined by radioimmunoassay. Results The serum levels of HA, Ⅳ-C and LN in cancer patients were significantly higher than those in normal control group and general disease group (P <0.05). There was no significant difference between the general disease group and normal control group (P> 0.05). Conclusions The changes of serum HA, Ⅳ-C and LN levels have reference value for the diagnosis, prognosis and prognosis of cancer patients.