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目的:探讨子痫前期患者Foxp3-3279和Foxp3-924基因位点多态性与子痫前期的相关性。方法:选择广州番禺区南村医院以及南沙第二人民医院、医科大学附属第三医院2010年10月至2014年12月收治的子痫前期患者156例子痫前期组,并选择同时期住院分娩的妊娠孕妇252例对照组,通过PCR-SSP技术对基因位点进行分析。结果:子痫前期组Foxp3-924G/G频率是0.1346,对照组是0.1508;子痫前期组G/A频率是0.4615,对照组是0.4087;子痫前期组A/A频率是0.4038,对照组是0.4087。子痫前期组Foxp3-924 A的遗传频率是0.6346,对照组是0.6346。子痫前期组Foxp3-924 G的遗传频率是0.3654,对照组是0.3552。Foxp3-924在子痫前期组和对照组的各方面比较的数值差距较小,差异均无统计学意义(P>0.05)。子痫前期组Foxp-3279位点基因型A/A、C/A、C/C频率与对照组以及A、C基因频率之间的数值差距比较小。结论:Foxp3-924、Foxp3-3279两者的位点基因多态性并不存在明显的差别,所以不能构成子痫前期发病原因的一部分。
Objective: To investigate the relationship between Foxp3-3279 and Foxp3-924 polymorphisms in preeclampsia and preeclampsia. Methods: 156 cases of preeclampsia group were selected from Nancang Hospital of Panyu District, Guangzhou City, the Third People’s Hospital of Nansha and the Third Affiliated Hospital of Medical University from October 2010 to December 2014, and the same period of hospitalization was chosen 252 pregnant women, the control group by PCR-SSP technology to analyze the gene loci. Results: The frequency of Foxp3-924G / G in preeclampsia group was 0.1346 and that in control group was 0.1508. The G / A frequency in preeclampsia group was 0.4615 and that in control group was 0.4087. The A / A frequency in preeclampsia group was 0.4038. The control group was 0.4087. The genetic frequency of Foxp3-924 A in preeclampsia group was 0.6346 and that in the control group was 0.6346. The genetic frequency of Foxp3-924 G in preeclampsia group was 0.3654 and that in control group was 0.3552. There was no significant difference between Foxp3-924 in preeclampsia and control groups (P> 0.05). The frequency of A / A, C / A and C / C genotypes at Foxp-3279 locus in preeclampsia group was lower than that in control group and A and C genotypes. Conclusion: The polymorphisms of Foxp3-924 and Foxp3-3279 are not significantly different, so they can not form part of the pathogenesis of preeclampsia.