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目的观察凯时注射液与丹参多酚酸盐注射液联合治疗糖尿病慢性肾功能不全的临床疗效。方法 60例糖尿病肾病慢性肾功能不全患者随机分为治疗组和对照组,每组30例。在常规治疗基础上,治疗组采用凯时注射液及丹参多酚酸盐注射液联合治疗,而对照组采用尿毒清颗粒治疗,观察2组治疗前后尿素氮(BUN)、血肌酐(SCr)、内生肌酐清除率(Ccr)变化情况。结果治疗组总有效率(90%)明显高于对照组(60%)(P<0.01)。治疗后,治疗组BUN、SCr水平均明显下降,Ccr明显升高,而对照组治疗前后BUN、SCr、Ccr水平比较均无显著性差异。治疗组上述指标改善情况明显优于对照组。结论凯时注射液联合丹参多酚酸盐注射液治疗可有效改善糖尿病慢性肾功能不全患者的肾功能及临床症状。
Objective To observe the clinical effect of combination of Salvia miltiorrhiza injection and salvia miltiorrhiza polyphenols injection in the treatment of diabetic chronic renal insufficiency. Methods 60 patients with diabetic nephropathy chronic renal insufficiency were randomly divided into treatment group and control group, 30 cases in each group. On the basis of routine treatment, the treatment group was treated with Kai Shi injection and salvianolate injection, while the control group was treated with Niaoduqing granule. The levels of blood urea nitrogen (BUN), serum creatinine (SCr) Endogenous creatinine clearance (Ccr) changes. Results The total effective rate (90%) in the treatment group was significantly higher than that in the control group (60%) (P <0.01). After treatment, the levels of BUN and SCr in the treatment group were significantly decreased, Ccr was significantly increased, while the levels of BUN, SCr, Ccr before and after treatment in the control group showed no significant difference. The treatment group improved significantly above indicators than the control group. Conclusions Kaishi injection combined with salvianolate injection can effectively improve renal function and clinical symptoms in diabetic patients with chronic renal failure.