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目的:探讨溶血磷脂酸受体在肺癌诊断和转移中的研究价值。方法:本研究选取我院收治的良、恶性胸腔积液患者,检测两者的LPA的水平,同时对恶性胸腔积液患者进行手术,对其进行比例分期,比较其特征和LPA水平表达的关系。结果:恶性组LPA浓度显著高于良性组,两组结果差别显著(t=0.652,P=0.000);肿瘤分期越晚,LPA受体表达越高,分期之间具有显著差异,肺癌淋巴结转移患者的LPA受体表达显著高于非淋巴转移患者,具有统计学意义(P<0.05)。结论:LPA水平可以辅助鉴别良、恶性胸腔积液,同时LPA受体的表达可以提高肺癌发生的概率,而且参与了肺癌的转移和侵袭。
Objective: To investigate the value of lysophosphatidic acid receptor in the diagnosis and metastasis of lung cancer. Methods: In this study, patients with benign and malignant pleural effusion admitted to our hospital were enrolled in the study. The levels of LPA and LPA in both malignant and pleural effusion were measured. . Results: The LPA concentration in malignant group was significantly higher than that in benign group (t = 0.652, P = 0.000). The later the tumor stage, the higher the expression of LPA receptor was and the stage was significantly different. The patients with lymph node metastasis The expression of LPA receptor was significantly higher in patients with non-lymph node metastasis, with statistical significance (P <0.05). Conclusion: The level of LPA can be used to identify benign and malignant pleural effusions. At the same time, the expression of LPA receptor can increase the probability of lung cancer and participate in the metastasis and invasion of lung cancer.