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目的探讨抗结核治疗病史对乙型重型肝炎临床特点及预后的影响。方法通过对比有抗结核治疗病史的乙型重型肝炎85例患者与无抗结核病史的乙型重型肝炎123例患者,了解抗结核治疗病史对乙型重型肝炎的影响。结果与无抗结核病史的乙型重型肝炎比较,有抗结核治疗病史的乙型重型肝炎死亡率高(P=0.0062),住院天数延长(P=0.04),并发症(脾大、腹水、肝硬化、自发性腹膜炎)发生频率较高(P<0.05);凝血酶原时间、凝血酶原活动度、白蛋白、总胆红素、肌酐与无抗结核治疗病史的乙型重型肝炎比较差异有统计学意义(P<0.05)。结论抗结核治疗病史可以显著影响乙型重型肝炎的临床表现及预后。
Objective To investigate the history of anti-tuberculosis treatment of patients with severe hepatitis B clinical features and prognosis. Methods By comparing 85 patients with severe hepatitis B who have anti-TB treatment history and 123 patients with severe hepatitis B without history of anti-tuberculosis treatment, the author learned about the influence of anti-tuberculosis treatment history on severe hepatitis B. Results Compared with severe hepatitis B without history of anti-tuberculosis, the mortality rate of severe hepatitis B with anti-tuberculosis treatment was significantly higher (P = 0.0062), length of hospital stay (P = 0.04), complications (splenomegaly, ascites, liver Sclerosis and spontaneous peritonitis) (P <0.05). There was significant difference in prothrombin time, prothrombin activity, albumin, total bilirubin, creatinine and history of severe hepatitis B Statistical significance (P <0.05). Conclusion The history of anti-TB treatment can significantly affect the clinical manifestations and prognosis of severe hepatitis B.